21. Solution to Chemistry Problem
📂 Chemistry
👤 Derkach
Product Description
3. Calculate the quantitative content of levomycetin stearate in the substance (SP X, pp. 389-390).
Method of determination. About 0.04 g (exact weight) of levomycetin stearate is dissolved in 95% ethanol in a 100 ml volumetric flask and the volume of the solution is brought to the mark with ethanol (solution A). 10 ml of solution A are transferred to a 100 ml volumetric flask and the volume of the solution is brought to the mark with ethanol (solution B).
The optical density of the resulting solution B is determined on a spectrophotometer at a wavelength of 272 nm in a cuvette with a layer thickness of 10 mm. In parallel, the optical density of a 0.002% solution of a standard sample of levomycetin stearate is measured at a wavelength of 275 nm.
The optical densities of the test and standard solutions are 0.360 and 0.400, respectively. The exact mass of the drug is 0.0369 g.
Method of determination. About 0.04 g (exact weight) of levomycetin stearate is dissolved in 95% ethanol in a 100 ml volumetric flask and the volume of the solution is brought to the mark with ethanol (solution A). 10 ml of solution A are transferred to a 100 ml volumetric flask and the volume of the solution is brought to the mark with ethanol (solution B).
The optical density of the resulting solution B is determined on a spectrophotometer at a wavelength of 272 nm in a cuvette with a layer thickness of 10 mm. In parallel, the optical density of a 0.002% solution of a standard sample of levomycetin stearate is measured at a wavelength of 275 nm.
The optical densities of the test and standard solutions are 0.360 and 0.400, respectively. The exact mass of the drug is 0.0369 g.
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